This includes the number of novel mechanisms that has never before been discussed in previous monographs. View contacts for Aprea to access new leads and connect with decision-makers. Historically, treatment response rates in TP53 mutant AML patients have been poor regardless of therapy. There are two major variants of MCL, known as classical and leukemic non-nodal (L-NN). Senior Vice President and Chief Scientific Officer. We will be moving onto the number of outstanding shares. Dr. Korbel has more than 12 years of experience in the biotechnology and pharmaceutical industries. Conference ID: 3119839. Another factor to consider is Aprea Therapeutics's market cap, which is $ 147.67 million. BOSTON, Sept. 20, 2021 (GLOBE NEWSWIRE) -- Aprea Therapeutics, Inc. (Nasdaq: APRE), a biopharmaceutical company focused on developing and commercializing novel cancer therapeutics that reactivate the mutant tumor suppressor protein, p53, today presented data at the European Society of Medical Oncology (ESMO) Congress 2021 from its Phase I/II clinical trial in advanced solid tumors. Sequencing of a panel of commonly mutated genes, including TP53, is standard practice in the diagnosis of AML. Please email us at CustomerCareOnline@apria… with your full name, phone number, and reference number 4496443 so we can reach out to you. Beginning with postdoctoral work at Genentech, he has also worked at Biovitrum, Pharmacia&Upjohn, Pharmacia and KabiGen. After this long , I did not get anew breast pump because the money was never refunded. Found insideThe second part of the book gives an overview of privileged cyclic small molecules and major classes of natural product-derived small molecules, including carbohydrate-derived compounds, peptides and peptidomimetics, and alkaloid-inspired ... The mutations are usually related to resistance to anti-cancer drugs and poor overall survival, thereby representing a significant unmet medical need in cancer treatment, said Aprea Therapeutics. There are no established curative pharmacologic therapies for MDS or AML. Aprea Therapeutics can also be reached via phone at 609-510-4718 and via email at [email protected] Aprea Therapeutics Inc. - Insider Activity and Holdings. Currently, the stock has been recommended as Hold by 5 of the brokerage firms. The corporate mailing address for Dr. Korbel and other Aprea Therapeutics executives is 535 BOYLSTON STREET, BOSTON MA, 02116. Found insideThis volume offers a broad and interdisciplinary view of modern approaches to drug discovery as used by pharmaceutical companies and research institutes. TP53 mutation / del(17p) are the most frequent findings in MCL. P/E Ratio (TTM) The Price to Earnings (P/E) ratio, a key valuation measure, is calculated by dividing the stock . Register to place your order online or give us a call using Apria's 24-Hour Automated Phone System. View detailed APRE description & address. In addition, he received a Pediatric Oncology and Hematology degree and M.S. Fouad Namouni, M.D. Prior to Merrimack, he served as Senior Vice President and Head, Global Rare Diseases at Genzyme (Sanofi). At the close of trading, the stock's price was $4.30, to imply an increase of 2.63% or $0.11 in intraday trading. Bharat completes Covaxin studies in children. Found insideIn this book, world-renowned experts in the field express well-reasoned opinions on a range of issues and controversies relating to haploidentical transplantation with the aim of providing practicing hematologists with clinically relevant ... From 1989 to 2002, Mr. Coiante held management positions of increasing responsibilities at Ernst & Young LLP. APRE / Aprea Therapeutics Inc short sale volume is shown in the following chart. Aprea Therapeutics Inc. - Insider Activity and Holdings. In addition to consulting for venture capital and biotechnology firms, he formerly served as Senior Scientist at Invtirogen/Life Technologies. Include your full name and address, plus the number located in the shaded bar on the reverse side, and state that you want a paper copy of the meeting materials. Aprea Therapeutics Inc's number of analysts covering the stock is higher than 33.99% of Pharmaceutical Products stocks. The company offers p53, a tumor suppressor protein that responds to various forms of cellular stresses and activates transcription of genes that induce cell cycle arrest or . For general information, Learn About Clinical Studies. Allogeneic hematopoietic stem cell transplant (allo‑HCT) is currently the only recognized therapy believed to increase the likelihood of long term survival for TP53 mutant MDS and AML patients. Christian S. Schade is President, Chief Executive Officer & Director at Aprea Therapeutics AB. Aprea Therapeutics Inc. (NASDAQ:APRE)'s traded shares stood at 0.75 million during the last session. Historically, treatment response rates in TP53 mutant MDS patients have been poor regardless of therapy. News Aprea Therapeutics Inc.APRE. ×. — Phone - Call us free of charge at 1-866-641-4276. in clinical and experimental pharmacology from Université Paris-Sud in France. Aprea Therapeutics, Inc. Condensed Consolidated Balance Sheets (Unaudited) Senior Vice President and Chief Financial Officer. Richard Peters, M.D., Ph.D. has served as a member of our board of directors since June 2020. Mr. Kelly is a former senior executive of Amgen, Inc. and is currently acting as Founder & President of Sentry Hill Partners, LLC, a global life sciences transformation and management consulting business founded by Mr. Kelly in 2018. Found insideThe World Health Organization (WHO) Expert Committee on Specifications for Pharmaceutical Preparations advises the Director-General of WHO in the area of medicines quality assurance. This book provides basic, translational, and clinical cancer researchers an indispensable overview of immune escape as a critical trait in cancer and how applying specific combinations of immunotherapy and chemotherapy to attack this trait ... Include your full name and address, plus the number located in the shaded bar on the reverse side, and state that you want a paper copy of the meeting materials. Participant Dial in Number: US/CANADA Participant Toll-Free Dial-In Number: (855) 547-3866. Found inside – Page iiThis book provides a concise yet comprehensive overview of MDS. The book begins by reviewing the diagnostic workup of MDS, with a specific focus on the 2016 WHO criteria for MDS diagnosis, and the biology and pathophysiology of the disease. The all time high for this statistic is 11. Mr. Kelly joined the Aprea Therapeutics board in September 2020. There is no standard of care therapy for R/R MCL but ibrutinib is a preferred treatment option. Found inside – Page 734... Precision Biosciences, Aprea Therapeutics, and Fate Therapeutics and has received honoraria from Pharmacyclics, Janssen, AbbVie, Genentech, AstraZeneca, ... Aprea Therapeutics, Inc. (NASDAQ:APRE)'s traded shares stood at 478,434 during the last session, with the company's beta value hitting 0. This report presents the recommendations of a WHO Expert Committee commissioned to coordinate activities leading to the adoption of international recommendations for the production and control of vaccines and other biological substances and ... Korbel., Ph.D. has served as our Chief Business Officer since March 2021, having previously served as Vice President, Business Development since July 2016. More recently he served as Chief Scientific Officer at Affibody from 2004-2010 and as SVP of Protein Therapeutics at Algeta from 2010-2013. Email address. It involves in the development and commercialization of novel cancer therapeutics that reactivate mutant p53 tumor suppressor protein. In the week up to 5 September Aprea Therapeutics shares surged 9.32% to a closing position of $4.69. Found inside – Page 1960... A case of acute distigmine bromide intoxication in the therapeutic et al . ... Ponary helpslistephala and i 1,6 trichloro - pendinol Aprea JE DNA Repair ... Positions data for Aprea Therapeutics. US/CANADA Participant International Dial-In Number: (409) 217-8798. Found inside – Page 247... MI-219 (Asenta Therapeutics, Malvern, PA), PXN727 and PXN822 (Priaxon, ... of p53 and induction of tumor cell apoptosis, Aprea, Solna, Sweden) [179]. Dr. Attar received his medical degree from the University of North Carolina School of Medicine. AML is the most common form of adult leukemia, with the highest incidence in patients aged 60 years and older. MDS can develop de novo or may arise secondary to chemotherapy or radiation treatment for a different, prior malignancy or following an antecedent hematological disorder. Chairman and managing director of Bharat Krishna Ella said that Covaxin production would . Found insideEstablished almost 30 years ago, Methods in Microbiology is the most prestigious series devoted to techniques and methodology in the field. Found inside – Page 97Consumer Products and Their Manufacturers with Addresses and Phone Numbers ... Therapeutics - Chemical preparations - Sunsmart Inc. Applied Therapeutics ... APRE does have institutional investors; and they hold 42.90% of the stock. Mr. Kelly has also held positions at Biogen, Tanox and Monsanto Life Sciences. TP53 mutation occurs in up to 80% of NSCLC cases. The all time high for this statistic is 11. in Chemistry, both from the Royal Institute of Technology in Stockholm, Sweden. Aprea Therapeutics losses hedge funds. It is characterized by accumulation of malignant B lymphocytes in the outer edge, or mantle zone, of lymph node follicles. Seed, Series A, Private Equity), Alternate or previous names for the organization, Whether an Organization is for profit or non-profit, General contact email for the organization. p53 is the protein expressed from the TP53 gene, the most commonly mutated gene in cancer.We believe that mutant p53 is an attractive therapeutic target due to the high incidence of p53 . Mr. Henneman serves on the boards of directors of R1 RCM, Inc., a publicly-held revenue cycle technology and management services company, SeaSpine Holdings Corporation, a publicly-held medical technology company, and Alafair Biosciences, Inc., a privately-held medical device company. USA 535 Boylston St. Boston, MA 02116 USA. The Company's lead product candidate is eprenetapopt (APR-246), a small molecule . https://www.cancer.gov/types/bladder/patient/bladder-treatment-pdq. 98. Dr. Seizinger currently serves as chairman/board member in a number of public and private biotech companies in the U.S., Europe and Canada, including: Oxford BioTherapeutics, Aprea, CryptoMedix, Oncolytics and BioInvent. AML patients are segmented into different risk groups according to cytogenetic abnormalities. Our Pipeline. Christian S. Schade has served as our President and Chief Executive and as a member of our board of directors since June 2016, and was appointed Chairman of the board of directors in September 2020. Mr. Kelly is an independent member of the board of directors for publicly-traded DMC Global, Inc., NeoGenomics, Inc., and Hookipa Pharma, Inc. Our Company; The company has an average price target of $4.00. Aprea Therapeutics Inc. (APRE) saw downtrend of -1.46% in the recent trading with $4.04 being its most recent. APRE has an Overall Score of 10. from Vanderbilt University. Dr. Peters is a Harvard-trained physician and scientist, has served on the faculty at the Massachusetts General Hospital, and completed a Howard Hughes Medical Institute Fellowship in biophysics at Harvard Medical School. Prior to serving as Head of Oncology Development, Dr. Namouni was Head of Medical Affairs at BMS and prior to that position, he was Head of Development for Opdivo® and Yervoy®, immunotherapy medications used in the treatment of cancer. Put another way, you can use this information to find out if the firm . Updated review. has served as our Senior Vice President, Chief Medical Officer since April 2019. He received an A.B. We have also conducted two Phase 1b/2 investigator-initiated trials to evaluate the potential benefit of eprenetapopt + azacitidine combination in the frontline treatment of TP53 mutant myeloid malignancies, including MDS. Reading this book is the only way to have a specific strategy. This book offers you a chance to trade APRE Stock at predicted prices. Eight methods for buying and selling APRE Stock at predicted low/high prices are introduced. Company profile for Aprea Therapeutics Inc. including key executives, insider trading, ownership, revenue and average growth rates. Classical nodal MCL, accounting for 80-90% of cases, affects the lymph nodes and extra nodal sites. Lung cancer is the most common cancer worldwide and the leading cause of cancer-related death. Mr. Coiante received a B.S. Around 30% of patients diagnosed with MDS will progress to AML, with the rate being higher for patients with more advanced disease. Aprea Therapeutics, Inc. is a biopharmaceutical company headquartered in Boston, Massachusetts with research facilities in Stockholm, Sweden, focused on developing and commercializing novel cancer . Of these, classical MCL is the more aggressive disease. About Aprea Therapeutics, Inc. Aprea Therapeutics, Inc. is a biopharmaceutical company headquartered in Boston, Massachusetts with research facilities in Stockholm, Sweden, focused on developing . OUR PIPELINE. APRE does have institutional investors; and they hold 42.90% of the stock. SaaS, Android, Cloud Computing, Medical Device), Where the organization is headquartered (e.g. Insiders that have sold shares include Gregory Alan Korbel, Eyal C Attar, and Ventures Iv L.P. 5Am. Dr. Attar joined Aprea from Agios Pharmaceuticals, where he was Senior Medical Director and IDH Hematology Medical Lead. We can also take a look at the company's market cap. No news for in the past two years. Public Health and Infectious Diseases brings together chapters that explain reasons for the emergence of these infectious diseases. AAPL, FB, TWTR), Total amount raised across all funding rounds, Total number of Crunchbase contacts associated with this organization, Total number of employee profiles an organization has on Crunchbase, Total number of investment firms and individual investors, Descriptive keyword for an Organization (e.g. Ocugen Inc. (NASDAQ: OCGN) has announced that its India-based partner Bharat Biotech has finalized Phase 2 and 3 studies of its COVID-19 vaccine candidate, Covaxin, for children between 2 and 18 years. Aprea Therapeutics, Inc is primarely in the business of pharmaceutical preparations. Dr. Peters brings more than 25 years of experience developing new therapies for difficult-to-treat diseases. Found insideThus, the dual role of the tumor microenvironment is the integral focus of the volume. The volume highlights the bi-directional interactions between tumor cells and non-malignant tumor component during tumor progression and treatment. Bernd Seizinger, M.D., Ph.D., has served as a member of our board of directors since 2016. $999.993600. The reporting person undertakes to provide Aprea Therapeutics, Inc., any security holder of Aprea . The 52-week high for Aprea Therapeutics Inc is $30.99 and the low is $3.17. Read more. Dr. Abrahmsen received a Ph.D. in Biochemistry and an M.S. It is estimated that fewer than 10% of patients diagnosed with TP53 mutant MDS and AML undergo allo-HCT. As of the 27th of August, Aprea Therapeutics shows the risk adjusted performance of (0.045931), and Mean Deviation of 2.6.Aprea Therapeutics technical analysis gives you the methodology to make use of historical prices and volume patterns to determine a pattern that approximates the direction of the firm's future prices. The current price level -87.15% lower than the highest price of $31.45 marked by the stock while trading over the past 52-weeks, whereas it is 4.12% higher than the lowest price of $3.88 the company dropped to over past 52-weeks. Aprea Therapeutics, Inc. is a biopharmaceutical company headquartered in Boston, Massachusetts with research facilities in Stockholm, Sweden, focused on developing and commercializing novel cancer therapeutics that reactivate mutant tumor suppressor protein, p53. Aprea focuses on the discovery and development of novel anticancer compounds reactivating the tumor suppressor protein p53. During this period of time, the stock fell as low as $4.40 and as high as $5.59. Found inside – Page 171Furthermore, a large number of cancer drugs have not been linked to ... that could be used as biomarkers to specify their potential therapeutic efficacy. AML can develop de novo or may arise secondary to progression of other hematologic disorders or from chemotherapy or radiation treatment for a different, prior malignancy; secondary AML carries a worse prognosis than de novo AML. We are conducting a Phase 2 clinical trial to assess the safety and potential efficacy of eprenetapopt in combination with azaciditine as maintenance therapy after allo-HCT for patients with TP53 mutant MDS or AML. He currently serves as President, Chief Executive Officer and Director at Yumanity Therapeutics Inc. Dr. Peters joined Yumanity from Merrimack Pharmaceuticals, Inc. where he was President & Chief Executive Officer. US/CANADA Participant Toll-Free Dial-In Number: (855) 547-3866. 3, 4 and 5) . Currently, the stock has been recommended as Hold by 5 of the brokerage firms. Corp., a small molecule Relationship Science, the dual role of the year, aprea therapeutics phone number showing potential... 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